- Austin-Twyman Papers, 1765/193942
- Carter Family Papers, 1667/1862, bulk 1792/186135
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19499
- Robert Morton Hughes Papers, 1754/19509
- Wharton and Radford Families Papers, 1783/19068
- Cazenove Family Papers (MS212), 1786/19707
- James Washington Singleton Papers, 1770/1975, bulk 1850/19207
- Webb Family Papers, 1790/19757
- Emory L. Kemp Papers regarding Industrial History, 1735/20216
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20115
- Brown, Coalter, Tucker Papers (I), 1790/19294
- Jerdone Family papers, 1753/18904
- John Janney Papers,, 1811/1994, bulk 1840/18804
- Watts family papers-addition, 1786/19504
- Black, Kent, and Apperson Family Papers, 1779/19843