- E. H. Hook Diary, 1820/18712
- E. L. Mathers and Max Mathers, Compilers, Monongalia County Scrapbook, 1838/19511
- E.L. Armstrong, Letter regarding 1786 Land Grant in Harrison County, 18411
- Earhart Family Papers, 1788/19283
- Earl Gregg Swem Genealogy Collection, 1719/19826
- Earl L. Core (1902-1984) Papers, 1756/198516
- Earl L. Core, Collector, Papers, 1840/19271
- Easton-Avery Community History, 1769/19271
- Ebenezer Church of Barbour County, Membership Records, 1836/19211
- Edgar E. MacDonald papers, 1933/19931
- Edgerly Pierson and Sons Ledgers, 1835/18762
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edmonds Family Papers, 1790/18711
- Edmund J. Lee Papers, 1829/18492
- Edmund Ruffin, Jr. Farm Journal, 1841-1843, 1841/18432