- Southall Papers, 1807/1904565
- Cocke Family Papers, 1725-1939294
- Galt Papers (I), 1745/1892183
- Tucker-Coleman papers, 1664/1945, bulk 1770/1907148
- Carter Family Papers, 1667/1862, bulk 1792/186188
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Webb-Prentis Family Papers
1770-190871
- Papers relating to Edgar Allan Poe and John Henry Ingram's Poe collection, 1809/197052
- Tyler Family Papers, Group D, 1939/195151
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195447
- Papers of the Randolph Family of Edgehill, 1732/186038
- Haymond Family Papers, 1783/1867, bulk 1825/186732
- West Virginia Land Grants Records, 1748/191230
- Jerdone Family papers, 1753/189028
- Richard Kidder Randolph Family Papers
1791-193224