- Carter Family Papers, 1667/1862, bulk 1792/186137
- Austin-Twyman Papers, 1765/193936
- Brown, Coalter, Tucker Papers (I), 1790/192911
- Webb Family Papers, 1790/19758
- James Washington Singleton Papers, 1770/1975, bulk 1850/19207
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19497
- Cazenove Family Papers (MS212), 1786/19706
- Emory L. Kemp Papers regarding Industrial History, 1735/20216
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20115
- Jerdone Family papers, 1753/18905
- Robert Morton Hughes Papers, 1754/19505
- Wharton and Radford Families Papers, 1783/19065
- Black, Kent, and Apperson Family Papers, 1779/19843
- Blow Family Papers, 1613/1960, bulk 1770/18753
- Brown, Coalter, Tucker Papers (II), 1791/19203