- Adam Empie Papers, 1811/2004, bulk 1811/18502
- Adam Empie letters, 1833/18375
- Adam Rinica and George Rinica Account Book, 1822/18482
- Adams Papers, 1782/18902
- Addie Rogers Bound Sheet Music Collection, 1827/18603
- Administration records collection, 1776/19765
- Admiral John Randolph Tucker Papers, 1865/18972
- Advisory Committee Research Collection, 1772/20179
- Agreement between F. P. Blair and Charles Mason, 18352
- Aileen Shafer, Collector, Material regarding African-Americans, 1829/18848
- Alabama Collection, 1823/18932
- Albert R. Gallatin papers, 1795/18281
- Alderman family papers, 1779/19614
- Alexander Brown Papers (I), 1815/19103
- Alexander Brown Papers (II), 1748/19001