- Alexandria History Collection (MS240), 1767/20087
- Alexandria Library Company Records (MS002), 1794/20074
- Alexandria Scrapbook Collection (MS003), 1830/18931
- Armistead Boothe Papers (MS164), 1803/19903
- Cazenove Family Papers (MS212), 1786/19706
- Chapman Family Collection (MS274), 1828/19631
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Eleanor Lee Templeman Collection (MS061), 1810/19901
- Esther Holliday Green Collection (MS073), 1859/19825
- Ethelyn Cox Collection (MS287), 1956/19801
- John K. Pickens Papers (MS057), 1964/19761
- Milton Penn Collection (MS267), 1794/18933
- Montgomery Dent Corse Papers (MS065), 1846/19821
- Penny C. Morrill Collection (MS104), 1970/198010
- Phillip Fendall Papers (MS190), 1817/18571