- Carter Family Papers, 1667/1862, bulk 1792/186131
- Austin-Twyman Papers, 1765/193927
- Brown, Coalter, Tucker Papers (I), 1790/192911
- James Washington Singleton Papers, 1770/1975, bulk 1850/19206
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20115
- Cazenove Family Papers (MS212), 1786/19705
- Emory L. Kemp Papers regarding Industrial History, 1735/20215
- Jerdone Family papers, 1753/18905
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19495
- Wharton and Radford Families Papers, 1783/19065
- Robert Morton Hughes Papers, 1754/19504
- Blow Family Papers, 1613/1960, bulk 1770/18753
- Dangerfield Lewis papers, 1799/18543
- Gloucester Circuit of the Methodist Church Records, 1825/19103
- John Marshall Papers, 1755/18353