- Barker-Cooke Papers, 1809/1889, bulk 1848/18661
- Barron Family Papers, 1793/19422
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19983
- Benjamin A. Banks Papers, 1855/19741
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/18921
- Betty Washington Lewis family papers, 1783/18441
- Black, Kent, and Apperson Family Papers, 1779/19842
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20232
- Borland Family Papers, 1771/19402
- Braxton County (W. Va.) Court Records and Miscellaneous Papers, 1830/19532
- Broadside Collection, 1812/2013, bulk 1900/19501
- Brooke County (W. Va.) Court Records and Miscellaneous Papers, 1780/19183
- Brown, Coalter, Tucker Papers (I), 1790/19293