- Bell, Kent, Cloyd, Withrow Family Collection, 1780/199818
- Preston Family (Charles Peale Didier Collection) Papers, 1747/189717
- War of 1812 Collection, 1806/18238
- Dickson Family Papers, 1769/19247
- John Nicolay Papers, 1782/19837
- Preston Family (Alice Preston Moore Collection) Papers, 1749/18827
- Pauline E. Burks Family Papers, 1763/19856
- Wharton and Radford Families Papers, 1783/19066
- William Short Papers, 1785/19216
- Historical Maps Collection, 1500/20235
- Stearns Family Papers, 1714/19205
- Charles W. Crush Collection, 1796/19784
- Dillard-Larkin Family Papers, 1809/19554
- J. Hoge Tyler Family Collection, 1802/19564
- John Janney Papers, 1811/1994, bulk 1840/18804