- Anthony Buck Ledger, 1807/18141
- Armistead-Cocke Papers, 1680/19174
- Augusta County, Va. Ledger, 1801/18081
- Austin-Twyman Papers, 1765/19392
- B. J. Spruell Account Book, 1782/18361
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/18921
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18174
- Borland Family Papers, 1771/19401
- Cabell Family Papers, 1693/1913, bulk 1743/18237
- Campbell Family Papers, 1726/192011
- Carter Family Papers, 1667/1862, bulk 1792/186111
- Charles Brown Papers, 1792/18881
- Christopher Tompkins Papers, 1778/18382
- David A. Bucher Papers, 1769/19121