- Austin-Twyman Papers, 1765/193916
- Carter Family Papers, 1667/1862, bulk 1792/186111
- Brown, Coalter, Tucker Papers (I), 1790/19297
- Philip Lightfoot Papers, 1778/18007
- Dickson Family Papers, 1769/19245
- Jerdone Family papers, 1753/18905
- Bushrod Washington family papers, 1662/18354
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20113
- Borland Family Papers, 1771/19403
- Cazenove Family Papers (MS212), 1786/19703
- Emory L. Kemp Papers regarding Industrial History, 1735/20213
- James Washington Singleton Papers, 1770/1975, bulk 1850/19203
- John Marshall Papers, 1755/18353
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19493
- Robert Morton Hughes Papers, 1754/19503