- Eloise Word Skewis Papers, 1777/19072
- Emory L. Kemp Papers regarding Industrial History, 1735/20213
- Geo. Gregory Smart collection of Washington and Mount Vernon ephemera, 1793/20172
- Hart collection, 1762/19391
- Henkel Family Papers, 1783/18741
- Historic Maps of Europe, 1572/18451
- International Association for Identification Records, 1842/2012, bulk 1910/19591
- James Washington Singleton Papers, 1770/1975, bulk 1850/19203
- Jerdone Family papers, 1753/18905
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19951
- John Augustine Washington III and family papers, 1789/19941
- John G. Stewart Papers, 1761/2002, bulk 1953/19731
- John Marshall Papers, 1755/18353
- John Taylor of Caroline papers, 1777/17942
- John Tyler, Jr. Papers, 1800/19281