- Armistead-Cocke Papers, 1680/19172
- Austin-Twyman Papers, 1765/19393
- Barron Family Papers, 1793/19421
- Barry S. Martin collection of historical manuscripts and documents, 1771/18302
- Betty Washington Lewis family papers, 1783/18441
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Visitors records, 1757/20232
- Borland Family Papers, 1771/19402
- Brown, Coalter, Tucker Papers (I), 1790/19292
- Brown, Coalter, Tucker Papers (II), 1791/19201
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18991
- Cabaniss Family Papers, 1800/18371
- Cabell Family Papers, 1693/1913, bulk 1743/18232
- Carl R. Dolmetsch Papers, 1751/19901
- Carter Family Papers, 1667/1862, bulk 1792/18611