- Caperton family genealogical research files, 1938/19803
- Carl R. Dolmetsch Papers, 1751/19902
- Carol R. Lubin papers, 1960/19811
- Carpenter Papers, 1765/19221
- Carr-Cary Family Papers
1785-18394
- Carrington Family Papers, 1785/18301
- Carrington Surveys, 1785/18121
- Carter Family Papers, 1667/1862, bulk 1792/186124
- Catesby Jones Account Book, 1767/18452
- Cazenove Family Papers (MS212), 1786/19707
- Celestia "Essie" Wade Butler Smith papers, 1793/20023
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Chapin collection of Washington & Custis family documents, 1758/18294
- Chappelear Collection, 1788/19593
- Charles A. Miller Family Papers, 1708/19261