- Carter Family Papers, 1667/1862, bulk 1792/186111
- Austin-Twyman Papers, 1765/19397
- Brown, Coalter, Tucker Papers (I), 1790/19296
- Bushrod Washington family papers, 1662/18355
- Dickson Family Papers, 1769/19245
- Jerdone Family papers, 1753/18905
- Borland Family Papers, 1771/19403
- John Marshall Papers, 1755/18353
- Philip Lightfoot Papers, 1778/18003
- Robert Morton Hughes Papers, 1754/19503
- Blow Family Papers, 1613/1960, bulk 1770/18752
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/19002
- Emory L. Kemp Papers regarding Industrial History, 1735/20212
- James Washington Singleton Papers, 1770/1975, bulk 1850/19202
- John Taylor of Caroline papers, 1777/17942