- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Campbell Family Papers, 1726/19202
- Carr-Cary Family Papers
1785-18393
- Carter Family Papers, 1667/1862, bulk 1792/18615
- Cazenove Family Papers (MS212), 1786/19701
- Chapin-Horowitz Cynogetica Collection, 1836/20141
- Charles Campbell Papers, 1743/18961
- Charles and Thomas Frankland record books, 1740/18111
- Cocke Family Papers, 1725-19393
- Cocke and Related Family Papers, ca.1773-19921
- David A. Bucher Papers, 1769/19122
- Dickson Family Papers, 1769/19244
- Duke Family Papers
1764-19831
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Esther Maria Lewis Chapin collection of Washington family documents, 1743/18521