- Bryan Family Papers, 1780/18252
- Bucktrout-Braithwaite Papers, 1780/1996, bulk 1890/18993
- Bushrod Washington family papers, 1662/183519
- Byer Family Genealogy, 1726/19381
- C. Harrison Mann, Jr. map collection, 1579/19611
- C. L. Worthington Papers, 1752/19383
- Cabell Family Papers, 1693/1913, bulk 1743/18239
- Calvert Walke Tazewell Papers, 1900/19971
- Campbell Family Papers, 1726/19206
- Caperton family genealogical research files, 1938/19803
- Carl R. Dolmetsch Papers, 1751/19902
- Carol R. Lubin papers, 1960/19811
- Carpenter Papers, 1765/19221
- Carter Family Papers, 1667/1862, bulk 1792/186118
- Catesby Jones Account Book, 1767/18452