- 17th and 18th century British periodicals, 1600/18001
- Adams Papers, 1782/18901
- Alexander Balmaine Memorandum Book, 1775/18201
- Andrew Lindamood papers, 1768/18171
- Ann Sparshall Commonplace Book, 1783/17921
- Archibald Woods Papers, 1777/1846, bulk 1783/18463
- Armistead-Cocke Papers, 1680/19171
- Austin-Twyman Papers, 1765/19396
- Baird Family Papers, 1656/1922, bulk 1656/18484
- Barraud Family Papers, 1799/1904, bulk 1810/18601
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Benjamin Layman Papers, 1752/18151
- Bishop James Madison Papers (Photostats), 1777/18121
- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18121
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171