- Jerdone Family papers, 1753/18904
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19951
- John G. Stewart Papers, 1761/2002, bulk 1953/19731
- John Marshall Papers, 1755/18353
- John Taylor of Caroline papers, 1777/17941
- John W. Warner papers, 1967/2009, bulk 1967/20081
- Lexington Arsenal and Virginia Militia records, 1702/18391
- Manuscripts - Geographic Names, Business Names and Subjects, 1725/19492
- Mason C. Andrews Papers, 1777/2010, bulk 1950/19901
- Paul G. Caplan Papers, 1890/20041
- Philip Lightfoot Papers, 1778/18001
- Reid Family papers, 1760/18961
- Richard A. Rutyna Papers, 1763/20112
- Richard Billups Papers, 1705/1857, bulk 1774/18221
- Robert Morton Hughes Papers, 1754/19501