- A. E. Dick Howard papers, 1928/20171
- Administration records collection, 1776/19762
- Advisory Committee Research Collection, 1772/20174
- Alexander Balmaine Memorandum Book, 1775/18201
- Alexander Haight family collection, 1764/19761
- Ancella Bickley, Historian, Research Papers regarding African-Americans, 1775/2018, bulk 1970/20111
- Anderson Family papers, 1755/19581
- Andrew Lindamood papers, 1768/18171
- Anna Burton Ellett Collection, 1751/19322
- Archibald Woods Papers, 1777/1846, bulk 1783/18461
- Austin-Twyman Papers, 1765/19395
- Benjamin Layman Papers, 1752/18151
- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18121
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/187516