- Benjamin Layman Papers, 1752/18151
- Benjamin Owen Tyler calligraphic manuscript and Fenno family papers, 1770/18161
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- Bigler-Sessler-John Family Papers, 1752/19251
- Bishop James Madison Collection, 1776/18071
- Bishop James Madison's preparatory notes on Smith's Wealth of Nations, 1776/18121
- Blair Family Papers, 1741/17921
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18171
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Board of Trustees records, 1774/19661
- Board of Visitors records, 1757/20231
- Boots (Steiffel) and Peterson (Biedert) Families Genealogies, 1771/19851
- Borland Family Papers, 1771/19401
- Bowman Family Papers, 1765/19981
- Boyers Morgan Clark, Compiler, Genealogy Records, 1660/19551