- David A. Bucher Papers, 1769/19123
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- David Somervill Notebooks, 1768/17841
- Davidson Family Papers, 1773/19382
- Davis-Meranda Family of Clark County, Ohio, Genealogy, 1770/18501
- Dickson Family Papers, 1769/19249
- Dismal Swamp Collection, 1763/19281
- Doddridge Family Manuscript, 1745/18571
- Donovan H. Bond, Compiler, Research Papers regarding Vandalia Colony and West Virginia Forts, 1962/2002, bulk 1756/19951
- Dorothy McCombs Collection,, 1970/19891
- Duke Family Papers
1764-19831
- Dunmore Family Papers (I) [in part photocopies], 1650/18995
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/19853
- Easton-Avery Community History, 1769/19271