- Charles and Joseph Read commonplace book, 1765/17941
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/194518
- Christopher A. Dorrance collection, 1750/20001
- Christopher Beeler Will, 17731
- Clara L. Lawrence Papers, 1763/19393
- Clarence P. Jones, Jr. Papers, 1773/1915, bulk 1809/18212
- Cocke Family Papers,
1725-19391
- Cocke and Related Family Papers,
ca.1773-19922
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18582
- Colvin Papers, 1734/18392
- Conway Whittle Papers, 1773/1911, bulk 1801/18672
- Currency Collection, 1772/18991