- Earl Gregg Swem Genealogy Collection, 1719/19823
- Earl L. Core (1902-1984) Papers, 1756/19851
- Edgar E. MacDonald papers, 1933/19931
- Edith Moore Sprouse Papers (MS313), 1960/20031
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190015
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Eileen Peters, Compiler, Genealogy, 1887/199521
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18231
- Emory L. Kemp Papers regarding Industrial History, 1735/20214
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19822
- Ethelyn Cox Collection (MS287), 1956/19801
- Fairfax Harrison Papers, 1736/19456
- Galt Papers (I), 1745/18923
- Galt Papers (III), 1750/19915