- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19203
- Caperton family genealogical research files, 1938/19802
- Carter Family Papers, 1667/1862, bulk 1792/18612
- Catesby Jones Account Book, 1767/18451
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles Campbell Papers, 1743/18962
- Christian S. Hutter miscellany, 1602/194516
- Clara L. Lawrence Papers, 1763/19391
- Colvin Papers, 1734/18391
- Commissions of the Peace for Sussex County, Virginia, 1754/17711
- David A. Bucher Papers, 1769/19121
- Dickson Family Papers, 1769/19241
- Dorothy McCombs Collection, 1970/19891
- Dunmore Family Papers (I) [in part photocopies], 1650/18995