- 17th and 18th century British periodicals, 1600/18001
- Alexander Brown Papers (II), 1748/19001
- Andrew Lindamood papers, 1768/18172
- Archibald Stuart Ledgers, 1757/18521
- Armistead Papers, 1736/18971
- Armistead-Cocke Papers, 1680/19174
- Austin-Twyman Papers, 1765/19397
- Baird Family Papers, 1656/1922, bulk 1656/18483
- Bakers' Guild Bylaws and Register (Harburg, Germany), 1668/18091
- Barron Family Papers, 1793/19421
- Barry S. Martin collection of historical manuscripts and documents, 1771/18301
- Benjamin Layman Papers, 1752/18152
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- Blair Family Papers, 1741/17922
- Blair, Banister, Braxton, Horner, Whiting Papers, 1760/1890, bulk 1765/18173