- Charles Brown Papers, 1792/18881
- Charles Campbell Papers, 1743/18968
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Joseph Read commonplace book, 1765/17941
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/194513
- Christopher A. Dorrance collection, 1750/20001
- Clara L. Lawrence Papers, 1763/19393
- Cocke Family Papers, 1725-19391
- Cocke and Related Family Papers, ca.1773-19921
- Col. Dudley Digges Account from William & Mary, 1763/17652
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392