- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles Campbell Papers, 1743/18962
- Christian S. Hutter miscellany, 1602/194511
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18391
- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- Earl Gregg Swem Genealogy Collection, 1719/19823
- Earl L. Core (1902-1984) Papers, 1756/19851
- Edgar E. MacDonald papers, 1933/19931
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190015
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199519
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18231
- Elizabeth River Parish Vestry Book, 1749/17611
- Emory L. Kemp Papers regarding Industrial History, 1735/20213