- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/19853
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Eileen Peters, Compiler, Genealogy, 1887/199519
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Eliza H. Cocke Scrapbook, 1754/1823, bulk 18232
- Elizabeth River Parish Vestry Book, 1749/17612
- Emory L. Kemp Papers regarding Industrial History, 1735/20216
- English Autographs and Signatures Collection, 1710/19151
- English and American legal documents, 1559/18471
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- Esther Maria Lewis Chapin collection of Washington family documents, 1743/18522
- Ethelyn Cox Collection (MS287), 1956/19801