- Cocke Family Papers, 1725-19391
- Cocke and Related Family Papers, ca.1773-19921
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392
- Commissions of the Peace for Sussex County, Virginia, 1754/17711
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- Dickson Family Papers, 1769/19241
- Doddridge Family Manuscript, 1745/18571
- Donovan H. Bond, Compiler, Research Papers regarding Vandalia Colony and West Virginia Forts, 1962/2002, bulk 1756/19951
- Dunmore Family Papers (I) [in part photocopies], 1650/18995
- Earl Gregg Swem Genealogy Collection, 1719/19825
- Earl L. Core (1902-1984) Papers, 1756/19853
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19753