- Campbell Family Papers, 1726/19204
- Caperton family genealogical research files, 1938/19801
- Carl R. Dolmetsch Papers, 1751/19902
- Carol R. Lubin papers, 1960/19811
- Carter Family Papers, 1667/1862, bulk 1792/186120
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Chapin collection of Washington & Custis family documents, 1758/18293
- Charles A. Miller Family Papers, 1708/19261
- Charles Brown Papers, 1792/18881
- Charles Campbell Papers, 1743/18968
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/194511
- Christopher A. Dorrance collection, 1750/20001