- Shenandoah Valley Legal Documents, 1751/1968, bulk 1901/19351
- Stearns Family Papers, 1714/19201
- Steve Wolfe, Collector, Historical Newspapers, 1666/19951
- Stuart Family Papers, 1785/18801
- The Independent Collection, 1680/19601
- The University of Virginia Jefferson Papers, 1751/18981
- Thomas G. and Louise Rowe Pullen Collection, 1655/17911
- Tucker-Coleman papers, 1664/1945, bulk 1770/19071
- Virgil Anson Lewis Family History, Research Papers, 1750/20002
- Virginia Counties Collection, 1600/2000, bulk 1730/189025
- Washington and Lee University and Regional Virginia History Research Collection, 1609/20162
- Wilkin Family Papers, 1757/1922, bulk 1780/18701
- William K. Perrin Papers, 1732/1902, bulk 1820/18581
- Willis Guy Tetrick, Jr. Genealogy Research Papers, 1708/19971
- Woodbridge Mercantile Company Records, 1743/18821