- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- Esther Maria Lewis Chapin collection of Washington family documents, 1743/18522
- Ethelyn Cox Collection (MS287), 1956/19801
- European figure engravings, 1535/18491
- Facilities Management Records, 1678/20031
- Faculty Assembly Records, 1729/20083
- Fairfax Harrison Papers, 1736/19457
- Fairfax-Spencer family recipe book, 1694/17951
- Florence Montgomery, Compiler, Monongalia and Tyler Counties Genealogies, 1700/19501
- Fowler Family Papers, 1700/1943, bulk 1830/18601
- Francis P. Lee Papers, 1727/19301
- Galt Papers (I), 1745/18924
- Galt Papers (III), 1750/19912
- Gaspard Monge Portrait Print, 1746/18181