- Colvin Papers, 1734/18392
- David Hunter Strother, Artist, Artwork and Papers, 1744/1996, bulk 1833/18871
- Dickson Family Papers, 1769/19241
- Doddridge Family Manuscript, 1745/18571
- Dorothy McCombs Collection, 1970/19891
- Dunmore Family Papers (I) [in part photocopies], 1650/18995
- Earl Gregg Swem Genealogy Collection, 1719/19824
- Edgar E. MacDonald papers, 1933/19931
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Eileen Peters, Compiler, Genealogy, 1887/199518
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth River Parish Vestry Book, 1749/17612
- Emory L. Kemp Papers regarding Industrial History, 1735/20215
- English Autographs and Signatures Collection, 1710/19151
- English and American legal documents, 1559/18471