- George Wythe Collection, 1779/19272
- Henkel Family Papers
1791-18851
- Henry Rose Carter papers, 1775/19471
- Historic Maps of Europe, 1572/18451
- Historic ephemera collection, 1796/19861
- Historic manuscript collection, 1601/19332
- Irvine-Saunders Family Papers
1745-1910 Inclusive1
- Jerdone Family papers, 1753/18901
- Joseph C. Cabell and the Cabell Family papers
1731-19171
- Latane Family Papers
1650-189810
- Lee Nicholson Papers, 1827/19386
- Manuscripts Artifact Collection, 1800/20101
- Map Collection, 1629/19911
- McGavock Family Papers, 1760/18883
- Methodist Files, 1784/20241