- C. Harrison Mann, Jr. map collection, 1579/19611
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/182312
- Campbell Family Papers, 1726/19203
- Carol R. Lubin papers, 1960/19811
- Carter Family Papers, 1667/1862, bulk 1792/186118
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles A. Miller Family Papers, 1708/19261
- Charles Campbell Papers, 1743/18964
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19459
- Cocke and Related Family Papers, ca.1773-19921
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421