- John W. Warner papers, 1967/2009, bulk 1967/20081
- Joseph C. Cabell and the Cabell Family papers
1731-19171
- Latane Family Papers
1650-18989
- Livre pour la remede pour les chevaux [Book of the remedy for horses], 1741/17601
- Morris Family Papers
1727-19311
- Ollen Lawrence Burnette, Jr. papers, 1815/20141
- Papers of Mary Johnston1
- Papers of the Low Moor Iron Company
1873-19271
- Papers of the Preston and Related Radford Families,
1744-18953
- Papers of the Randolph Family of Edgehill, 1732/18602
- Quinby, Teackle, and Upshur families of Somerset County, Maryland, and Accomack and Northampton Counties, Virginia Papers, 1713/19771
- Record Book Listing of Enslaved People of the Massie Family, 1823/18631
- Richard J. DeMartino papers, 1910/19651
- Robert S. Pace Collection
1669-19932
- Robert and Ruth Carroll artifact and book collection, 1728/19401