- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199517
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953
- Emory L. Kemp Papers regarding Industrial History, 1735/20215
- English Autographs and Signatures Collection, 1710/19151
- English and American legal documents, 1559/18471
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19822
- European figure engravings, 1535/18491
- Facilities Management Records, 1678/20031
- Faculty Assembly Records, 1729/20083
- Fairfax Harrison Papers, 1736/19451