- Carter Family Papers, 1667/1862, bulk 1792/186117
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles A. Miller Family Papers, 1708/19261
- Charles Campbell Papers, 1743/18962
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Charles and Thomas Frankland record books, 1740/18112
- Chester McNerney Collection, 1290/19501
- Christian S. Hutter miscellany, 1602/19459
- Cocke and Related Family Papers, ca.1773-19921
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Colvin Papers, 1734/18392
- Dickson Family Papers, 1769/19241
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19823