- Elizabeth Fairfax cookbook, 1694/17953
- Faculty Assembly Records, 1729/20083
- Historic ephemera collection, 1796/19863
- Historical Maps Collection, 1500/20233
- J. Paul Hudson Papers, 1930/19983
- Jack Eric Morpurgo Papers, 1937/2000, bulk 1950/19703
- Jack Sandy Anderson, Compiler, Local History Articles and Genealogy Papers, 1600/2011, bulk 2000/20083
- Lexington Arsenal and Virginia Militia records, 1702/18393
- Manley Family papers, 1707/19533
- Maupin-Washington Papers, 1732/19323
- Overton family papers, 1727/1961, bulk 1781/18753
- Performing arts manuscripts collection, 1475/19843
- Richard Billups Papers, 1705/1857, bulk 1774/18223
- Richard G. Joynt Collection of British Manuscripts, 1593/20153
- Robert Hunt Land Papers, 1938/19423