- Blow Family Papers, 1613/1960, bulk 1770/18752
- Board of Visitors records, 1757/20231
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Campbell Family Papers, 1726/19201
- Carter Family Papers, 1667/1862, bulk 1792/18612
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Dunmore Family Papers (I) [in part photocopies], 1650/18991
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Ephemera Collection, 1800/20141
- Fairfax Harrison Papers, 1736/19451
- George Mason Papers, 1706/18581
- J. Paul Hudson Papers, 1930/19983
- Jack Eric Morpurgo Papers, 1937/2000, bulk 1950/19703
- James Hughes Letter to the Governors of the College of William & Mary, 17281
- Jerdone Family papers, 1753/18901