- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001
- Edwin W. Lynch Vietnam War protest collection, 1965/19756
- Eileen Peters, Compiler, Genealogy, 1887/199512
- Elise S. Billmyer, Collector, Papers, 1636/19611
- Elizabeth Fairfax cookbook, 1694/17953
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- English and American legal documents, 1559/18471
- Ephemera Collection, 1800/20141
- Esther Holliday Green Collection (MS073), 1859/19821
- European figure engravings, 1535/18491