- C. Harrison Mann, Jr. Map Collection, 1579/19611
- C. Harrison Mann, Jr. map collection, 1579/19611
- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Carol R. Lubin papers, 1960/19812
- Carter Family Papers, 1667/1862, bulk 1792/18616
- Channing Moore Hall Papers, 1920/1953, bulk 1930/19531
- Charles Shetler, Curator and Historian, Papers, 1700/19651
- Chester McNerney Collection, 1290/19502
- Christian S. Hutter miscellany, 1602/19459
- Collection of French Language Manuscripts, 1633/1942, bulk 1633/19421
- Collection of Spanish Language Manuscripts, 1551/18581
- Cotton Mather Ephesians sermons, 1702/17061
- Dunmore Family Papers (I) [in part photocopies], 1650/18997
- Edgar E. MacDonald papers, 1933/19931
- Edward Vitale violin music collection, 1700/19001