- Blow Family Papers, 1613/1960, bulk 1770/18753
- Bruton Parish Church (Williamsburg, Va.) records, 1662/2010, bulk 1900/20003
- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Jack Sandy Anderson, Compiler, Local History Articles and Genealogy Papers, 1600/2011, bulk 2000/20083
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19953
- Morley Jeffers Williams Collection, 1602/19673
- Robert Hunt Land Papers, 1938/19423
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/19603
- Tyler Family Papers, Group G, 1645/19173
- Armistead-Cocke Papers, 1680/19172
- Benefactions of Francis Nicholson, Esqr. to the Church & Clergy in North America, 1689/17042
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- George Washington collection, 1654/17992
- Hill Family Genealogy, 1700/1999, bulk 1980/19992