- The Independent Collection, 1680/19602
- The Thirty Fifth State, Manuscript and Galley, 1609/19601
- Thomas G. and Louise Rowe Pullen Collection, 1655/179115
- Thruston family commonplace book, 1604/19251
- Title Transcription: Alexander Mackay-Smith Collection, 1689/18271
- Tucker-Coleman papers, 1664/1945, bulk 1770/19074
- Tyler Family Papers, Group D, 1939/19513
- Tyler Family Papers, Group G, 1645/19173
- Tyler Family Papers, Group H, 1750/19351
- University Archives Artifact Collection, 1693/2014, bulk 1900/20111
- University Archives Bound Volumes Collection, 1693/19932
- Upshur Family Papers, 1662/19362
- Virginia Cities Collection, 1663/19802
- Virginia Counties Collection, 1600/2000, bulk 1730/189015
- Virginia Records, 1623/19211