- Dunmore Family Papers (I) [in part photocopies], 1650/18992
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- George Washington collection, 1654/17992
- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- Historic manuscript collection, 1601/19332
- Historic map collection, 1675/19712
- J. Paul Hudson Papers, 1930/19982
- Jack Eric Morpurgo Papers, 1937/2000, bulk 1950/19702
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- John Mason Diary, 1694/17022
- John N. Paden papers, 1938/20102
- John Womack Wright Collection of Maps, 1675/19182
- King William III and Queen Mary II Papers, 1689/17102
- Latane Family Papers
1650-18982