- Bushrod Washington family papers, 1662/18353
- Cabell Family Papers, 1693/1913, bulk 1743/18233
- Dunmore Family Papers (I) [in part photocopies], 1650/18993
- Edwin W. Lynch Vietnam War protest collection, 1965/19753
- Jack Sandy Anderson, Compiler, Local History Articles and Genealogy Papers, 1600/2011, bulk 2000/20083
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19953
- King William III and Queen Mary II Papers, 1689/17103
- Morley Jeffers Williams Collection, 1602/19673
- Office of the President. James Blair Records, 1695/17473
- Robert Hunt Land Papers, 1938/19423
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/19603
- Tyler Family Papers, Group D, 1939/19513
- Tyler Family Papers, Group G, 1645/19173
- Benefactions of Francis Nicholson, Esqr. to the Church & Clergy in North America, 1689/17042
- Brafferton Estate Collection, 1691/19352