- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19953
- Performing arts manuscripts collection, 1475/19843
- Tyler Family Papers, Group D, 1939/19513
- Tyler Family Papers, Group G, 1645/19173
- "Area Ecclesiae Cathedralis Lincolniae" etching, 16722
- Blow Family Papers, 1613/1960, bulk 1770/18752
- Bushrod Washington family papers, 1662/18352
- Chester McNerney Collection, 1290/19502
- English Receipt and Home Remedy Manuscript Book, 1665/17042
- George Washington collection, 1654/17992
- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- Historic manuscript collection, 1601/19332
- J. Paul Hudson Papers, 1930/19982
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762