- Wade Hampton Frost papers, 1880/19843
- Blow Family Papers, 1613/1960, bulk 1770/18752
- C. Harrison Mann, Jr. map collection, 1579/19612
- Cambridge University Charters, 1575/16692
- Chester McNerney Collection, 1290/19502
- Hill Family Genealogy, 1700/1999, bulk 1980/19992
- Historic Map and Government Documents Collection, 1630/19782
- James M. Guiher, Jr., Papers, 1835/2014, bulk 1927/19762
- Morley Jeffers Williams Collection, 1602/19672
- Sheet Music Collection, 1827/19742
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19322
- W. Jett Lauck papers, 1900/19522
- 17th and 18th century British periodicals, 1600/18001
- A. E. Dick Howard papers, 1928/20171
- Belgii Novi. Angliæ Novæ, et partis virginiæ Novissima Delineatio (reproduction), 16501