- Lee Nicholson Papers, 1827/19385
- Morton Genealogy Collection, 1830/19783
- Tyler Family Papers, Group D, 1939/19513
- Wade Hampton Frost papers, 1880/19843
- Berkeley Family Papers
1536-present1
- C. Harrison Mann, Jr. map collection, 1579/19611
- Henkel Family Papers
1791-18851
- Henry Rose Carter papers, 1775/19471
- Jim Comstock, Newspaper Editor and Collector, Papers, 1650/2003, bulk 1850/19951
- Latane Family Papers
1650-18981
- Manuscripts Artifact Collection, 1800/20101
- Papers of the Low Moor Iron Company
1873-19271
- Thruston family commonplace book, 1604/19251
- Von Frieling's Salve collection, 1512/1977, bulk 1900/19321